• Dr. Alla Arutcheva


Updated: Mar 26, 2019

Multifactoral Elucidation of Atopic Dermatitis

Eczema is a skin disorder that may result in multiple effects on quality of life. Eczema is not only skin diseases but it involves other body organs and systems. Eczema is a general term for many types of skin inflammation (mostly atopic dermatitis, contact irritant eczema and contact allergic eczema) and may appear anywhere on the body.

Hand eczema is a common dermatological disorder in adults. This complication has annual prevalence of 10% and may cover more than 4% of the population (1).

Irritant contact eczema is a localized reaction that includes redness, itching, and burning where the skin has come into contact with an irritant such as a detergent (soap, body wash), some acids or other chemicals and some fabric.

Allergic contact eczema is a red, itchy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign, such as nickel, gold, latex, perfume, poison ivy or certain preservatives in creams and lotions. Most cases of contact dermatitis (irritant and allergic) go away on their own once the substance is no longer in contact with the skin.

Atopic dermatitis (AD) is the most common and sever type of eczema and has a genetic mutation in their skin protein called filaggrin (1).

Some people can have a combination of different types of eczema.

Chronic exposure to irritants, frequent washing hands, using disinfectants, wet-work conditions disturbs the natural skin barrier and causes inflammation.

Symptoms of Eczema

Signs and symptoms of eczema vary widely from person to person and include: • Dry, sensitive and swollen skin •

Itching, which may be severe, especially at night •

Red or brown patches •

Raised bumps with fluid •

Thickened, cracked, scaly skin

Atopic dermatitis/Eczema

Although the pathophysiology of or atopic dermatitis (AD) has not been fully elucidated, it is currently believed to be due to a combination of genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors (2).

Our skin is a reflection of the inner health. In recent decades, a growing body of evidence demonstrates that AD and any other ‘skin disease’, can be accompanied by a variety of systemic disorders. Multiorgan involvement can be possible common underlying mechanisms of AD.

Multifactorial Elucidation of Atopic Dermatitis

Gut‐skin axis

Several dermatoses, including eczema, appear to have a gut‐skin connection (3). Eczema may be seen as a possible manifestation of a systemic problem involving gut dysbiosis and increased intestinal permeability (leaky gut), which may occur even in the absence of gastrointestinal signs.

Conventional anti‐inflammatory and antimicrobial therapies for skin disorders provide only temporary symptomatic relief. However, underlying factors such as intestinal permeability (4) and dysbiosis are mostly ignored. In addition, antibiotic therapy contributes to the development of antibiotic‐resistant microbes (5), destroy normal intestinal flora (Lactobacilli and Bifidobacteria) and promote overgrowth of Candida species.

AD has been found to be three times more common in patients with celiac disease than others (6,7).

Eczema and skin rash have also been reported in the people with ‘non‐celiac gluten sensitivity’ (8,9).

Skin lesions and atopic dermatitis are significantly associated with inflammatory bowel disease (IBD) (10).

Small intestinal bacterial overgrowth (SIBO) is being linked to a list of human health problems, including skin conditions (11). SIBO treatment in these patients has led to marked clinical improvement (12). Possible reasons for skin lesion development in SIBO include nutritional deficiency; impaired lipid metabolism; impaired immune‐system functioning; increased intestinal permeability. Intestinal bacteria produce a toxin (LPS), which spread all over the body with subsequent damage to the skin structure and barrier function (13).

Liver and skin

Our liver has numerous vital functions. One of the liver’s important roles is breaking down and eliminating toxins in the body. In case of AD and other skin problems the liver is not functioning optimally, becomes congested and less effective at broken down and eliminating toxins. So, these toxins are forced to be eliminated via the skin that damage and inflame the skin and resulting in different skin diseases. The weak liver function impacts the skin and provoke itching, rash, vesicles and cracking of the skin (14,15). AD is highly associated with changes in lipid metabolism regulated by the liver (16 17). Hence, poor skin quality is an indicator of weak liver function.

Minimizing stress

Over 80 years ago, two dermatologists, Stokes & Pillsbury (18) proposed a connection between gastrointestinal disorders, depression, anxiety and skin conditions and called it gut‐brain‐skin axis (19). It was suggested that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Since then, many aspects of this gut‐brain‐skin axis have been validated (11).

It was shown that stress can impair the integrity and protective function of the epidermal barrier of skin, and increase the severity of infection and inflammation in the skin (20,21).

Alternative Approaches

Many patients are very interested in alternative therapies for the treatment of eczema. Alternative therapies encompass a wide range of possibilities. Natural treatment is perceived to be lower in risk than conventional therapies (22).


There are many types of diets that are recommended for eczema, including dairy free, gluten-free, low-allergen, no sugar, no dyes, no yeasty foods, alkaline foods, and many, many more.

Eating natural, organic, unprocessed and balanced foods with allergic food avoidance is the best diet for people with eczema.

One-third of AD patients have hypersensitivity food allergies (23) that can aggravate skin condition. An evaluation for food allergy should be considered.

Wheat ingestion can cause symptoms of eczema (24). Many cereals, including wheat, rye and barley, contain gluten (9) and a high level of fermentable carbohydrate.

Diet low in fermentable carbohydrates is preferable for people with AD.


Patients with eczema have disrupted bacterial flora both on the skin and in the gut. Disruptions in normal gut flora have been found not only in people with AD but also with other skin disorders including acne (25,26).

A recent meta-analysis concluded that treatment with probiotics significantly improve skin condition and should be used for prevention and treatment of human AD (27,28. Great benefit showed treatment of skin disorders with a mixture of different bacterial species of Lactobacillus with Bifidobacterium. Some probiotic strains such as Lactobacillus rhamnosus GG display potent immune‐modulatory properties at the skin level and seemed to be effective in preventing human AD and reducing the severity of AD (29).


There are a number of vitamins that may help with eczema. Studies show that more severe eczema is correlated with lower levels of vitamin D. Supplementing vitamin D can help eczema. Another study demonstrated increased benefit from combining vitamin D with vitamin E supplementation (30). Topical vitamin D while helpful in psoriasis may actually flare eczema.

Vitamin B12 ointment

Topical B12 ( Vitamin B-12 cream, Life-Flo) has been shown to successfully improve atopic dermatitis in both children and adults (31). It was demonstrated that, despite the size of the molecule, the skin is permeable to vitamin B12. The proposed mechanism is nitric oxide synthase inhibition, an important step in one AD inflammation pathway (32,33).

Nitric oxide (NO)

There are three forms of nitric oxide synthesized in the human body. However, one form of NOS, the inducible NO synthase (iNOS) has been found to be involved in the pathogenesis of atopic eczema and psoriasis (34,35) and stimulate inflammation process in the skin (36).

A feeling of irritation and itching of the skin causing a desire to scratch, is the most constant distressing symptom in atopic dermatitis. An explanation for this effect would be the detection of iNOS in the skin with atopic dermatitis. In the normal skin iNOS is absent. Nitric balance supplement need to reduce iNOS expresion.

Fatty acid

A deficiency in essential fatty acids (EFA) of the skin is one factor suspected of playing a role in eczema. Atopic eczema may be a minor inherited abnormality of EFA metabolism (37). Encouraging results were noticed when combined omega-3 and omega-6 fatty acid treatment with vitamins A and D (38).

Evening primrose oil (EPO) and borage seed oil (BO) are two “natural” supplements that have been frequently used as a treatment for eczema. Both are high in gamma-linolenic acid (GLA), a substance which may play a role in eczema.

Sunflower seed oil (Helianthus annuus) has been shown to have both anti-inflammatory and barrier restoring effects. Its major lipid is linoleic acid, which decrease inflammation in the skin and improve the skin barrier (39).

Olive oil was found to be detrimental to the skin barrier.

Virgin coconut oil (Cocos nucifera) has shown benefit as both an excellent emollient and natural antibacterial agent (40,41).

Moisturizers (emollients)

Epidermal barrier failure can be controled with moisturizers. Moisturizers are a daily part of skin care in atopic dermatitis and patients often use a variety of products based on personal preferences. Cracks in the skin lead to water loss from the skin and this can trigger an inflammatory response and infection.


Homeopathy has recently increased in popularity among patients with skin disease. Atopic eczema is one of those diseases where homeopaths claim to have good success. (42). Several studies suggests that homeopathic treatment could be regarded as an effective choice for patients with AD (43); 88% of complete recovery was reported (44).


People with eczema have a wool intolerance (45). Wearing alternative fabrics such as cotton and silk is recommended (46). The use of fabrics impregnated with borage oil-treated garments, gloves (for people with hand eczema) improve skin moisture and restore lipids (47).

Massage, relaxation, water bath, hypnosis, and aromatherapy have been explored as complimentary approaches in treatment of AD.

As you can see many factors may contribute to the chronic skin disease, including psychological factors (emotional stress, stressful life events), weak function of liver, impaired intestinal tract. Therefore, effective management of treatment should not be limited only skin.

Individualized treatment of eczema with the holistic approach can be developed after whole body health evaluation, including stress level determination.

Based on evaluation results Dr. Arutcheva will design a useful strategy to heal eczema.


1. Thyssen JP, Carlsen BC, Menne T, et al. Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study. Br J Dermatol. Jul 2010;163(1):115-120.

2. Bieber T. Atopic dermatitis. N Engl J Med. Apr 3 2008;358(14):1483-1494.

3. Ali IA FNaSR. Considering the Gut-Skin Axis for Dermatological Diseasis. Austin Journal of Dermatology. 2014;1024(1).

4. Ünsal H. BMGatieGNRoOFFeXQ, pp 107–150. InTech, Croatia. Glucocorticoids and the intestinal environment. Glucocorticoids–New Recognition of Our Familiar Friend. 2012.

5. Fujimura KE, Slusher NA, Cabana MD, Lynch SV. Role of the gut microbiota in defining human health. Expert review of anti-infective therapy. Apr 2010;8(4):435-454.

6. Fasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med. Dec 20 2012;367(25):2419-2426.

7. Ojetti V, De Simone C, Aguilar Sanchez J, et al. Malabsorption in psoriatic patients: cause or consequence? Scand J Gastroenterol. Nov 2006;41(11):1267-1271.

8. Catassi C, Bai JC, Bonaz B, et al. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients. Sep 26 2013;5(10):3839-3853.

9. Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. Feb 7 2012;10:13.

10. Ardizzone S, Puttini PS, Cassinotti A, Porro GB. Extraintestinal manifestations of inflammatory bowel disease. Dig Liver Dis. Jul 2008;40 Suppl 2:S253-259.

11. Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future? Gut Pathog. Jan 31 2011;3(1):1.

12. Parodi A, Sessarego M, Greco A, et al. Small intestinal bacterial overgrowth in patients suffering from scleroderma: clinical effectiveness of its eradication. Am J Gastroenterol. May 2008;103(5):1257-1262.

13. Kell D.P. and Pretorius E. . . On the translocation of bacteria and their lipopolysaccharides between blood and periperhal locations in chronic inflammatory diseases: the central roles of LPS and LPS‐induced cell death. Integrative Biology. 2015(7):1339.

14. Bujalkova M, Straka S, Jureckova A. Hippocrates' humoral pathology in nowaday's reflections. Bratisl Lek Listy. 2001;102(10):489-492.

15. Emtiazy M, Keshavarz M, Khodadoost M, et al. Relation between Body Humors and Hypercholesterolemia: An Iranian Traditional Medicine Perspective Based on the Teaching of Avicenna. Iran Red Crescent Med J. Mar 2012;14(3):133-138.

16. Seino S TY, Honma T, Yanaka M, Sato K, Shinohara N, Ito J, Tsuduki T, Nakagawa K, Miyazawa T, Ikeda I. Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse. J Clin Biochem Nutr. 2012;Mar;50(2):152-157.

17. Hansen AE, Knott EM, et al. Eczema and essential fatty acids. Am J Dis Child. Jan 1947;73(1):1-18.

18. D.H. SJHaP. The effect on the skin of emotional and nervous states: theoretical and practical consideration of a gastrointestinal mechanism. . Archives of Dermatology and Syphilology. 1930(22):962-993.

19. Arck P, Handjiski B, Hagen E, et al. Is there a 'gut-brain-skin axis'? Exp Dermatol. May 2010;19(5):401-405.

20. Aberg KM, Radek KA, Choi EH, et al. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest. Nov 2007;117(11):3339-3349.

21. Slominski A. A nervous breakdown in the skin: stress and the epidermal barrier. J Clin Invest. Nov 2007;117(11):3166-3169.

22. Schlichte MJ, Vandersall A, Katta R. Diet and eczema: a review of dietary supplements for the treatment of atopic dermatitis. Dermatol Pract Concept. Jul 2016;6(3):23-29.

23. Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA. Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics. Mar 1998;101(3):E8.

24. Varjonen E, Vainio E, Kalimo K. Antigliadin IgE--indicator of wheat allergy in atopic dermatitis. Allergy. Apr 2000;55(4):386-391.

25. Katta R, Desai SP. Diet and dermatology: the role of dietary intervention in skin disease. J Clin Aesthet Dermatol. Jul 2014;7(7):46-51.

26. Volkova LA, Khalif IL, Kabanova IN. [Impact of the impaired intestinal microflora on the course of acne vulgaris]. Klin Med (Mosk). 2001;79(6):39-41.

27. Kim SO, Ah YM, Yu YM, Choi KH, Shin WG, Lee JY. Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol. Aug 2014;113(2):217-226.

28. Panduru M, Panduru NM, Salavastru CM, Tiplica GS. Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies. J Eur Acad Dermatol Venereol. Feb 2015;29(2):232-242.

29. Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol. 2008;9(2):93-103.

30. Javanbakht MH, Keshavarz SA, Djalali M, et al. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis. J Dermatolog Treat. Jun 2011;22(3):144-150.

31. Goddard AL, Lio PA. Alternative, Complementary, and Forgotten Remedies for Atopic Dermatitis. Evid Based Complement Alternat Med. 2015;2015:676897.

32. Januchowski R. Evaluation of topical vitamin B(12) for the treatment of childhood eczema. Journal of alternative and complementary medicine (New York, N.Y.). Apr 2009;15(4):387-389.

33. Stucker M, Pieck C, Stoerb C, Niedner R, Hartung J, Altmeyer P. Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dermatol. May 2004;150(5):977-983.

34. Rowe A, Farrell AM, Bunker CB. Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses. Br J Dermatol. Jan 1997;136(1):18-23.

35. Sirsjo A, Karlsson M, Gidlof A, Rollman O, Torma H. Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes. Br J Dermatol. Apr 1996;134(4):643-648.

36. Ormerod AD, Copeland P, Hay I, Husain A, Ewen SW. The inflammatory and cytotoxic effects of a nitric oxide releasing cream on normal skin. The Journal of investigative dermatology. Sep 1999;113(3):392-397.

37. Horrobin DF. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr. Jan 2000;71(1 Suppl):367S-372S.

38. Bjorneboe A, Soyland E, Bjorneboe GE, Rajka G, Drevon CA. Effect of n-3 fatty acid supplement to patients with atopic dermatitis. Journal of internal medicine. Supplement. 1989;731:233-236.

39. Eichenfield LF, McCollum A, Msika P. The benefits of sunflower oleodistillate (SOD) in pediatric dermatology. Pediatr Dermatol. Nov-Dec 2009;26(6):669-675.

40. Intahphuak S, Khonsung P, Panthong A. Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharmaceutical biology. Feb 2010;48(2):151-157.

41. Verallo-Rowell VM, Dillague KM, Syah-Tjundawan BS. Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis. Dermatitis : contact, atopic, occupational, drug. Nov-Dec 2008;19(6):308-315.

42. Smolle J. Homeopathy in dermatology. Dermatol Ther. 2003;16(2):93-97.

43. Eizayaga JE, Eizayaga JI. Prospective observational study of 42 patients with atopic dermatitis treated with homeopathic medicines. Homeopathy. Jan 2012;101(1):21-27. 44. Itamura R. Effect of homeopathic treatment of 60 Japanese patients with chronic skin disease. Complement Ther Med. Jun 2007;15(2):115-120.

45. Bendsoe N, Bjornberg A, Asnes H. Itching from wool fibres in atopic dermatitis. Contact Dermatitis. Jul 1987;17(1):21-22.

46. Ricci G, Patrizi A, Bendandi B, Menna G, Varotti E, Masi M. Clinical effectiveness of a silk fabric in the treatment of atopic dermatitis. Br J Dermatol. Jan 2004;150(1):127-131. 47. Kanehara S, Ohtani T, Uede K, Furukawa F. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. The Journal of dermatology. Dec 2007;34(12):811-815.

Antalee Wellness Spa

1834 Glenview  Rd, suite  2M (second floor)

Glenview, IL  60025

Phone: (847) 486-1130

email: dr.alarutchev@gmail.com