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Autoimmune Disorders

autoimmunity

Autoimminity

  • Bottom line: Whether you have undiagnosed symptoms or health problems, gastrointestinal malfunction, and autoimmune disease in your family, you may have autoimmunity.

More and more people today are developing chronic illnesses, pain, and unresolved conditions that have not been diagnosed as a disease. Patients spend years going from one doctor to the next, trying to find an answer to their health problems

The warning symptoms of autoimmune disorder are fatigue, dizziness, headaches, blurry vision, dry mouth and eyes, insomnia, skin problem, anxiety and depression, gastrointestinal tract problem, and achy joints disorders. Autoimmune diseases are among the most challenging to diagnose. 

Autoimmune epidemic is taking place worldwide.

These individuals are suffering from chronic inflammatory responses to various triggers such as diet, stress, and toxic pollutants. Recently, three major inflammation factors have become increasingly connected: gluten sensitivity, intestinal permeability (leaky gut), and autoimmunity. Gluten sensitivity leads to a leaky gut, and gluten sensitivity and leaky gut have been shown to be major triggers for an autoimmune disorder. 

The term "autoimmune disease" refers to various illnesses involving almost every human organ and system. It includes diseases of the nervous, gastrointestinal, and endocrine systems, as well as skin and other connective tissues, joints, eyes, blood, and blood vessels. The most common manifestation of an autoimmune disorder is Hashimoto disease (thus, Hashimoto’s is not a thyroid disease but an immune disorder), celiac disease, pernicious anemia, ulcerative colitis, Crohn’s disease, and rheumatoid arthritis.

Predisposing factor s for development of autoimmune diseases

Besides all these factors, loss of intestinal barrier function (leaky gut) is necessary to develop autoimmunity. Nevertheless, the onset of autoimmune diseases remains enigmatic.

Predisposing factors

The host predisposition could result from genetic factors that gene-environment interactions could trigger. In some families, a mother may have lupus; her son, juvenile diabetes; her sister, antiphospholipid syndrome; and her grandmother, rheumatoid arthritis.

In all of these diseases, the body's immune system becomes misdirected and attacks its own organs that it was designed to protect.

The etiology of autoimmune disease is multifactorial.

The triggers of autoimmune diseases include:

  • Genetic factor

  • Hormonal imbalance (ex: estrogen shifts, insulin resistance)

  •  Immunological factors. Defects in the regulation of immune T and B cells 

  • Bacteria, viruses, candida, parasites

  • Stress

  • Toxic drugs

  • Chemical irritants, heavy metals

  • Composition of gut microbiota

  • Obesity

  • Gluten intolerance

  • Vitamin D deficiency

AUTOIMMUNE DISORDER OF THE BRAIN

Common area of autoimmune attack is the brain and nervous system.

The youngest example of neuroautoimminity is autism. Immunological studies found that autism develops during pregnancy. When a woman goes into a pregnancy with a leaky gut, dysglycemia, and adrenal fatigue, it increases the risk of developing health disorders, including autism.

     Neuromyelitis optica and Multiple sclerosis are recognized autoimmune disease

stages

Autoimmune diseases have a period of flare up and remission. 

Components of the laboratory exam include complete blood count, comprehensive metabolic panel, inflammatory markers (C-reactive protein and Erythrocyte sedimentation rate) and autoantibodies. Autoimmunity is identified by measuring antibodies to self-tissue. Elevated measure of self-tissue antibodies is an indication of autoimmunity.

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